Schizophreniform Disorder Related Hospitalizations: A Clinical and Demographic Analysis of a National Hospitalization Database
DOI:
https://doi.org/10.20344/amp.21714Keywords:
Hospitalization, Psychotic DisordersAbstract
Introduction: Schizophreniform disorder manifests itself with similar symptoms to schizophrenia, but it is distinguished from the latter by its shorter duration, varying between at least one and six months. This study aimed to describe and analyze schizophreniform disorder related hospitalizations in a national hospitalization database.
Methods: We planned a descriptive retrospective study using a nationwide hospitalization database containing all hospitalizations registered in Portuguese mainland public hospitals from 2008 to 2015. Hospitalizations with a primary diagnosis of schizophreniform disorder were selected based on the International Classification of Diseases version 9, Clinical Modification (ICD-9-CM) code of diagnosis 295.4x. Data regarding birth date, sex, residence address, diagnoses, length of stay, discharge status, and hospital charges were obtained. Comorbidities were analyzed using the Charlson Index Score. Independent Sample t tests were performed to assess differences in continuous variables with a normal distribution and Mann-Whitney-U tests when no normal distribution was registered.
Results: In Portuguese mainland public hospitals, a total of 594 hospitalizations with a primary diagnosis of schizophreniform disorder occurred during the eight-year study period. Most, 72.1% (n = 428), were observed in male patients. The mean age at admission was 34.34 years in male patients and 40.19 years in female patients. The median length of stay was 17.00 days and in-hospital mortality was 0.5% (n = 3). Only 6.1% (n = 36) of the hospitalization episodes had one or more registered comorbidities. Forty-one readmissions were documented.
Conclusion: Hospitalizations with a primary diagnosis of schizophreniform disorder occur more frequently in young male patients. This is, to the best of our knowledge, the first nationwide study analyzing all hospitalizations due to this diagnosis in Portugal.
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References
Skikic M, Arriola JA. First episode psychosis medical workup: evidence-informed recommendations and introduction to a clinically guided approach. Child Adolesc Psychiatr Clin N Am. 2020;29:15-28.
Gaebel W, Zielasek J. Focus on psychosis. Dialogues Clin Neurosci. 2015;17:9-18.
Schrimpf LA, Aggarwal A, Lauriello J. Psychosis. Continuum. 2018;24:845-60.
Langfeldt G. Definition of “schizophreniform psychoses”. Am J Psychiatry. 1982;139:703.
American Psychiatric Association. Diagnostic and statistical manual of mental health disorders. 3rd ed. Washington: APA; 1980.
Strakowski SM. Diagnostic validity of schizophreniform disorder. Am J Psychiatry. 1994;151:815-24.
Zarate CA Jr., Tohen M, Land ML. First-episode schizophreniform disorder: comparisons with first-episode schizophrenia. Schizophr Res. 2000;46:31-4.
Bromet EJ, Schwartz JE, Fennig S, Geller L, Jandorf L, Kovasznay B, et al. The epidemiology of psychosis: the Suffolk County Mental Health Project. Schizophr Bull. 1992;18:243-55.
Strakowski SM, Tohen M, Stoll AL, Faedda GL, Mayer PV, Kolbrener ML, et al. Comorbidity in psychosis at first hospitalization. Am J Psychiatry. 1993;150:752-7.
American Psychiatric Association. Diagnostic and statistical manual of mental health disorders. 5th ed. Washington: APA; 2022.
World Health Organization. International statistical classification of diseases and related health problems. 11th ed.. Geneva: WHO; 2019.
World Health Organization. International statistical classification of diseases and related health problems. 10th ed.. Geneva: WHO; 2016.
World Health Organization. International statistical classification of diseases and related health problems. 9th ed.. Geneva: WHO; 2009.
Benazzi F. Outcome of schizophreniform disorder. Curr Psychiatry Rep. 2003;5:192-6.
Ochoa S, Usall J, Cobo J, Labad X, Kulkarni J. Gender differences in schizophrenia and first-episode psychosis: a comprehensive literature review. Schizophr Res Treatment. 2012;2012:916198.
Segarra R, Ojeda N, Zabala A, Garcia J, Catalan A, Eguiluz JI, et al. Similarities in early course among men and women with a first episode of schizophrenia and schizophreniform disorder. Eur Arch Psychiatry Clin Neurosci. 2012;262:95-105.
Kendler KS, Walsh D. Schizophreniform disorder, delusional disorder and psychotic disorder not otherwise specified: clinical features, outcome and familial psychopathology. Acta Psychiatr Scand. 1995;91:370-8.
Moini J, LoGalbo A, Ahangari R. Chapter 18: Schizophrenic disorders. In: Foundations of the Mind, Brain, and Behavioral Relationships Understanding Physiological Psychology. Cambridge: Academic Press; 2023. p.305-17.
Sautter F, McDermott B, Garver D. The course of DSM-III-R schizophreniform disorder. J Clin Psychol. 1993;49:339-44.
Crumlish N, Whitty P, Kamali M, Clarke M, Browne S, McTigue O, et al. Early insight predicts depression and attempted suicide after 4 years in firstepisode schizophrenia and schizophreniform disorder. Acta Psychiatr Scand. 2005;112:449-55.
Jäger M, Riedel M, Schmauss M, Pfeiffer H, Laux G, Naber D, et al. Depression during an acute episode of schizophrenia or schizophreniform disorder and its impact on treatment response. Psychiatry Res. 2008;158:297-305.
Troisi A, Pasini A, Bersani G, Di Mauro M, Ciani N. Negative symptoms and visual behavior in DSM-III-R prognostic subtypes of schizophreniform disorder. Acta Psychiatr Scand. 1991;83:391-4.
Rössler W, Salize HJ, van Os J, Riecher-Rössler A. Size of burden of schizophrenia and psychotic disorders. Eur Neuropsychopharmacol. 2005;15:399-409.
Instituto Nacional de Estatística. Estatísticas de Saúde 2017. Lisboa: INE; 2019.
Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373-83.
Portugal. Order nr. 132/2009. Official Gazette, Series 1, nr. 21 (2009/01/30). p.660-758.
Uggerby P, Nielsen RE, Correll CU, Nielsen J. Characteristics and predictors of long-term institutionalization in patients with schizophrenia. Schizophr Res. 2011;131:120-6.
Usall J, Araya S, Ochoa S, Busquets E, Gost A, Marquez M, et al. Gender differences in a sample of schizophrenic outpatients. Compr Psychiatry. 2001;42:301-5.
Gonçalves-Pinho M, Ribeiro JP, Freitas A. Schizophrenia related hospitalizations - a big data analysis of a national hospitalization database. Psychiatr Q. 2021;92:239-48.
Stralin P, Hetta J. Substance use disorders before, at and after first episode psychosis hospitalizations in a young national Swedish cohort. Drug Alcohol Depend. 2020;209:107919.
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